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In compact quantities the pressure hormone cortisol is amazingly helpful, but constantly raised levels of it are badโ€ฆ for just about every little thing. Weโ€™ve been carrying out some digging about in old scientific journals, and thankfully thereโ€™s an quick way to lessen the quantity of cortisol in your physique by thirty to forty %. Take 25 mg DHEA every day, and Bobโ€™s your [anticatabolic] uncle.

25 mg DHEA/every day
The cortisol-decreasing aspect of DHEA supplementation is not our personal discovery. A reader sent us the YouTube clip beneath, in which Jeff Anderson advises guys who want to drop fat in the chest location to take 25 mg DHEA every day. Fat deposition in this location is partly due to cortisol, says Anderson, and you can lessen your cortisol level by taking a low dose of DHEA each and every day.

Study 1
Whether or not guys can essentially drop pec fat by taking DHEA we do not know, but the concept that DHEA supplementation reduces the cortisol level holds water. At least, we located a study accomplished in 2003, in which researchers at the University of Pittsburgh got 69-year-old guys and females to take 200 mg DHEA each and every day for 15 days. [J Clin Psychopharmacol. 2003 Feb;23(1):96-9.]

Supplementation began on day eight and continued till day 22. The bars in the figures beneath show the quantity of cortisol in the blood of the participants on every single of these days.

The reduction in cortisol level as a outcome of the DHEA was higher in the females than in the guys. Though the menโ€™s cortisol levels did go down, the reduction was not statistically substantial on all days.

Study two
A every day dose of 200 mg DHEA is on the higher side. Researchers use a dose of 50 mg DHEA per day in most research. In 2006 Italian researchers published the final results of a study on the impact of a significantly reduce dose of DHEA on cortisol levels. [Gynecol Endocrinol. 2006 Nov;22(11):627-35.]

The Italians gave their test subjects โ€“ females aged involving 50 and 55 [dark bars on the figure below] and involving 60 and 65 [light coloured bars] โ€“ a every day 25 mg DHEA for a period of 12 months. = cortisol level ahead of DHEA supplementation began two = right after three months three = right after six months four = right after 12 months.

The figure above shows how DHEA supplementation may well operate. It shows the impact of the administration of 10 micrograms ACTH on the cortisol level, ahead of administration, and right after three, six and 12 months. ACTH is the messenger hormone that stimulates the adrenals to release cortisol. ACTH secretion increases beneath pressure. It appears that DHEA supplementation tends to make the adrenals much less sensitive to ACTH.

Conclusion
If you are pondering of attempting to reduce your cortisol level by taking DHEA, you will possibly notice most impact if you take the prohormone ahead of you go to sleep. For the duration of your sleep your DHEA level will peak. Your cortisol level will also peak when you are asleep, so inhibiting the cortisol will be most helpful at that moment. Sounds logical, does not it?

Extended-term low-dose oral administration of dehydroepiandrosterone modulates adrenal response to adrenocorticotropic hormone in early and late postmenopausal females.

Abstract

OBJECTIVE:
The aging method is related with a decline in the circulating Delta5-androgen dehydroepiandrosterone (DHEA) and its sulfate ester, dehydroepiandrosterone sulfate (DHEAS). The present study aimed to evaluate the effects of a extended-term (12 months) oral DHEA administration (25 mg/day) on adrenal function, ahead of and right after three, six and 12 months of therapy.

System:
Postmenopausal females belonging to two age groups, 50-55 years (n = 10) and 60-65 years (n = 10), have been studied. Adrenal function was assessed in basal situations, right after suppression with dexamethasone (DXM) and following a stimulation test with adrenocorticotropic hormone (ACTH) (10 microg bolus). Serum levels of DHEA, DHEAS, androstenedione (Delta4-A), allopregnanolone, 17-hydroxyprogesterone (17-OHP) and cortisol have been measured and the effects of DHEA supplementation on particular adrenal enzymatic pathways have been evaluated by calculating precursor/item ratios (17-OHP/cortisol, 17-OHP/Delta4-A, DHEA/Delta4-A and DHEA/DHEAS).

Final results:
DHEA supplementation annulled the age-connected variations in DHEA and DHEAS levels and induced a marked enhance in all steroids, except for cortisol, right after three-six months of therapy. Serum cortisol levels decreased from the 3rd month, each in younger and older subjects. DHEA supplementation did not have an effect on DXM-induced suppression of adrenal steroidogenesis. For the duration of the therapy period all adrenal androgens and progestins showed a substantial enhance in their response to ACTH, when the cortisol response decreased drastically. The final results recommend a substantial DHEA-induced adjust in adrenal enzymatic activities, as also evidenced by the adjust in precursor/item ratios through therapy.

CONCLUSION:
Chronic DHEA administration is capable of modifying circulating levels of androgens and progestins in each early and late postmenopausal females by modulating the age-connected adjustments in adrenal function.

PMID: 17145649 DOI: 10.1080/09513590601024681 [Indexed for MEDLINE]

Supply: https://www.ncbi.nlm.nih.gov/pubmed/17145649

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